Endocrine Abstracts

Introduction: Subclinical hypothyroidism (SCHT) in pregnancy has been associated with adverse obstetric and perinatal outcomes. However, few studies have investigated the evolution of postpartum thyroid function in women first diagnosed with SCHT in pregnancy (gestational SCHT).Objective: To determine the evolution of thyroid function (TF) and the clinical and biochemical factors related to the long-term persistence of hypothyroidism (HT) in women with g...

Aim: To evaluate the prevalence and incidence of type 2 diabetes in patients with nonfunctioning adrenal incidentalomas (NFAI) and autonomous cortisol secretion (ACS) coming from a cohort of adrenal incidentalomas consecutively evaluated in a tertiary hospital in a predefined period (2013-2020).Methods: In this retrospective study, adrenal incidentalomas ≥1cm with ACS and NFAI were included. ACS was defined by a post-dexamethasone suppression test ...

Background: Children who were born small for gestational age (SGA) and who do not have adequate catch-up growth until 4 years old have indication for treatment with recombinant human growth hormone (rhGH). The metabolic consequences of this treatment are relatively unknown. Objective: To evaluate the effect of rhGH treatment on insulin sensitivity and lipid profile.Materials and methods: A retrospective observational study of child...

Objective: To study the differences in the metabolic profile of patients with non-functioning adrenal adenomas (NFA) and autonomous cortisol secretion (ACS).Methods: 143 patients diagnosed of adrenal incidentaloma (AI) between 2010 and 2018 were retrospectively analyzed. AI was defined as an adrenal mass≥1 cm, accidentally discovered by radiologic examination. ACS was confirmed by serum cortisol post-dexamethasone suppression test (Nugent)≥3 ...

Introduction: Type 2 diabetes (T2D) is a heterogeneous disease for which causal mechanisms are incompletely understood and subclassification may improve patient management. In the latest assessment of patients with adult-onset diabetes, Ahlqvist and colleagues (2018) defined five new subgroups: an autoimmune form, two severe forms (insulin-deficient and insulin-resistant diabetes) and two mild forms (obesity and age-related diabetes).Objectives:...

Introduction: Ultrasound guided Fine-Needle Aspiration (USFNA) of Thyroid is the gold standard for diagnosis of thyroid nodules. Nowadays, many patients are under anticoagulation and antiplatelet medication. Some of the rare complications of USFNA are haemorrhage therefore it’s not clear if performing thyroid USFNA in hypo-coagulated patients increase that risk of complications or if this medication should be stopped before the procedure. Additionally the influence that t...

The authors report the clinical case of a 59-year old female who had vague complaints of impaired vision, fatigue and diffuse pain for more than a year before medical evaluation at our hospital. At the ophthalmology appointment, bitemporal hemianopsia was evident. Brain MRI was the diagnostic test of choice and revealed a mass involving de sellar and suprassellar space, causing compression of the optic chiasm, as well as osteolytic lesions in cranial vault. The patient was the...

Introduction: Prediabetes is a very prevalent disease. About 27.4% of Portuguese adults suffer from this condition. Prediabetes is defined as intermediate hyperglycemia state associated with the simultaneous presence of insulin resistance and β-cell dysfunction as diabetes, with increased risk of developing macro and microvascular complications. Approximately 7% of individuals with prediabetes will progress to diabetes per year. This study aims to characterize a populatio...

Introduction: Hypertriglyceridemia (hyperTG) may increase the risk of cardiovascular disease and values above 1000 mg/dl are a risk factor for pancreatitis, including non-fasting measurements. The American Heart Association suggested that providers could use nonfasting triglycerides >200 mg/dl to identify hyperTG states. When an elevated result is observed, a fasting triglyceride measure may be reassessed, with exception for extreme levels (for example approximately 1000 m...

Introduction: Although thyroid nodules (TN) are less common in children than in adults, the risk of malignancy is much higher in pediatric age and therefore representing greater concern in this age group.Objective: Evaluate a cohort of pediatric patients with TN and search differences between subjects with malignant and benign TN regarding sex, age, compressive symptoms, cervical ultrasound characteristics, family history of differentiated thyroid cancer...